Mercury poisoning (Medicardium)

  • 11 years ago
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The toxic dose for mercury compounds is about 10-50 mg/kg. Mercury is poorly absorbed from the gut and ingestion is usually harmless (unless aspiration occurs). A single dose (eg, a broken thermometer) usually causes no problems. It is only slowly absorbed through the skin but can cause contact dermatitis.

In the mid-1950s to 1968 the people of Minamata, Japan suffered chronic mercury poisoning from pollution from a local factory (Minamata disease). 'Mad as a hatter' is derived from poisoning among hatmakers who used mercuric nitrate to soften the hair of animal hides.

Acute poisoning:

An acute pneumonitis (± adult respiratory distress syndrome (ARDS)).
Flu-like symptoms.
Irritability.
Myalgia.
Gastrointestinal upset.
Subsequent peripheral neuropathy, hepatic dysfunction or renal failure may develop.

Chronic poisoning:

Irritability.
Personality changes.
Headache.
Peripheral neuropathy.
Memory problems.
Ataxia.
Coma.
Respiratory problems (pneumonitis and ARDS).
Gastrointestinal upset (abdominal pain, gingivitis and stomatitis, nausea, vomiting).
Renal problems include acute renal failure, nephrotic syndrome and acute tubular necrosis.

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