Nanobody treatment targets Hendra and Nipah viruses

Queensland Country Life

A University of Queensland team has identified the first nanobody proven to work against the deadly Nipah and Hendra viruses, which currently have no approved vaccine or cure. Video edited by Toby McGee.

Transcript

00:00So this is a structure that was determined at the Center for Microscopy and Microanalysis here at UQ.

00:05What it represents is the fusion glycoprotein of nipovirus that is represented here in pink,

00:10green and blue. So it's a trimeric protein and in yellow what we have is the DS-90

00:16nanobody that can bind deep into a crevice that is present on this fusion glycoprotein.

00:21So the nanobody binds and it stays there and it neutralizes the virus by preventing the fusion

00:28glycoprotein from changing its conformation and shape and preventing the virus from fusing with

00:33the host cell. This is a structure of the fusion glycoprotein that was determined here at the

00:38Center for Microscopy and Microanalysis at UQ. So the fusion glycoprotein is represented here in blue,

00:44pink and green and the DS-90 nanobody is here in yellow and once the DS-90 body binds into this

00:50deep pocket within the spike fusion glycoprotein it can bind and then it can neutralize the virus.

00:58the

01:11so

01:13you

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