The Good Doctor Season 4 Episode 7

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The Good Doctor Season 4 Episode 7  #TheGoodDoctor #ShowMoviesTV

Transcript

00:00We can't both shower at the same time, Leah.

00:20One of us would block the stream of water for the other.

00:22Oh, Sean, this is not for the purpose of cleanliness.

00:25This is for the purpose of having sex with you.

00:29Oh.

00:31No, no, it would be inconvenient.

00:34Possibly dangerous.

00:35Soap might get into difficult places

00:38if we leaned against the shower handle.

00:39We could scald ourselves.

00:40Bottles could be disarranged.

00:43It was just a thought.

00:45It was a bad thought.

00:47I'm surprised you're such an intelligent person.

00:51I'll reset your line.

00:53It's a three-day weekend and a full moon.

01:00People are going to do stupid things.

01:01I'm asking everyone to take an extra trauma call in the ER.

01:04Make yourselves available if you're needed.

01:06Questions?

01:09How'd you get the bruise?

01:10First casualty of the full moon.

01:12I smacked my head on the cupboard door

01:13when I was reaching for my coffee mug.

01:15Any other questions?

01:16Why is there a Subaru in your parking space?

01:19Because it's my car.

01:20You have a car?

01:21You're going to be seeing a lot of it.

01:22I sold the Ducati.

01:23What? No.

01:24It just wasn't practical.

01:26Is it already gone?

01:26Because...

01:27Guy from Craigslist snatched it up.

01:29Any other questions?

01:31Not dealing with the bike.

01:35It wasn't that much of a bruise.

01:37But the doctor at the ski resort

01:39told us I might develop a hematoma.

01:41It's not unusual, but it will need to be drained.

01:44I see you were treated for melanoma six years ago

01:47and more recently breast cancer.

01:50Hence the ski trip.

01:51A celebration.

01:53One year cancer-free.

01:55Also five years cancer-free.

01:58I don't suppose a long needle will be involved in this?

02:02Your hematoma extends pretty deep,

02:04so the needle will have to be long.

02:06But it's over quickly.

02:07Sorry, I have to intervene before this deal goes south.

02:09You don't mind if I step out?

02:13Would you like us to wait for your husband to come back?

02:16No.

02:18Let's go ahead.

02:22How do you get frostbite in San Jose?

02:24Cryotherapy accident.

02:26I stayed in the booth a little too long.

02:28I was going to stand outside for the full three minutes,

02:30but he said...

02:30I said no need.

02:31I'd set the stopwatch on my phone,

02:33after which my thoughts immediately drifted and...

02:36I came back to find him frozen and carbonized.

02:39You know, I'm more worried about the fever.

02:41Was the cryotherapy meant to treat something?

02:43No, routine self-care.

02:44We've made life extension part of our health regime.

02:47Supplements, meditation, exercise.

02:49Three of my gaming apps have gone viral.

02:51I'm lucky enough to afford basically whatever I want.

02:54I spend it on my health.

02:57I figure fever must be an infection.

03:00I know that frostbite can make you vulnerable.

03:03It just, it didn't seem severe enough.

03:08I'm sorry, I feel a little queasy here.

03:11Wait.

03:17I need a medical transport team stat.

03:24Perforated bowel.

03:24He needs immediate surgery.

03:36No, no.

03:37Why do people hate wind farms?

03:38Everyone thinks they're noisy.

03:40This could make a turbine sound as quiet as a page turning in a library.

03:43That's not worth our investing in.

03:45Did you even look?

03:46Hold on.

03:47Anything I need to know?

03:48Hematoma's drained.

03:49We're sending a sample to pathology.

03:51Routine should have it back sometime tomorrow.

03:55I couldn't help overhearing a little.

03:58Are you a venture capitalist?

04:00The only people who ask me if I'm a VC are people who want a VC to invest in their project.

04:07Maybe after we get your wife healthy again, we could talk.

04:11Whenever you're ready, my life is listening to ideas.

04:14If it's good, I'll run it by my two partners.

04:15If it's really good, we'll take a 30% equity position in your company.

04:27I think I've been asked out on a date.

04:31Nice.

04:32I work with him.

04:33Hasn't stopped you before?

04:34I supervise him.

04:35Schedules can be changed.

04:36He's polyamorous.

04:39Unless he also texted you a ring.

04:40It's just a date and you need to get out more.

04:44So do I.

04:46You want to take down the splenicolic ligament?

04:54Just don't nick the inferior mesenteric artery.

04:57I feel the IMA under my finger.

05:01Placing the stapler and cutting.

05:06I voted approve.

05:10Disapprove.

05:12No opinion.

05:13There's a poll?

05:14Yes, about shower sex.

05:17I know it's wrong to discuss shower sex at work, so I did a poll instead.

05:21Much better.

05:22Dr. Murphy, do you really want people knowing the details of your personal life?

05:27You don't think they took it as an abstract question?

05:30No, we all take it as something that happened between you and Leah.

05:33And that there was a fight.

05:34Sometime before 8am today, which was when the poll was sent out.

05:39You are very astute.

05:41I'm seeing diffused dilation of the large bowel here.

05:44Is that normal?

05:46Some calcified lesions.

05:50The wall's thin, too.

05:52Hirschsprung's?

05:52I thought Hirschsprung's was a disease only babies and young children got.

05:56It is.

05:58But he has it.

06:07We treated the Hirschsprung's by removing the dilated part of your colon.

06:11It won't impact her life, but we would like an explanation.

06:14Dr. Murphy doesn't mean we expect you to be a diagnostician.

06:17It's just, this was kind of singular.

06:20So if you have any thoughts, did anyone in your family suddenly develop these symptoms?

06:29I did something singular to myself about six months ago.

06:34I modified my genetic code.

06:36I did a CRISPR procedure under the guidance of some researchers I know in China.

06:40Through my work, they put together a series of cocktails.

06:42They FedExed them to me, and Sophie helped me inject them into my bone marrow.

06:48Why?

06:49If you know anything about CRISPR, you know how risky it is to tinker with your genome.

06:53You have no idea what problems you might let loose.

06:55But I needed to optimize my telomerase activity.

06:58It's the enzyme responsible for correcting cell replication errors,

07:01essentially the cause of aging.

07:02You can't stop aging through changing your telomerase activity.

07:05You might extend your life a little, but exercise, it does the same thing.

07:10Much less risky.

07:12Your decision makes no sense.

07:13Extending my life by a few years is only my short-term goal.

07:17Look, you know how fast medicine is moving.

07:19The day isn't that far away when cloning will make transplants

07:22as easy as switching out a light socket.

07:24AI will start to make breakthroughs that we can't predict or understand.

07:27Medical knowledge will rise exponentially.

07:30There are babies born now who could live to see it.

07:33Could live to be a thousand years old.

07:35Maybe more, maybe forever.

07:37Or at least as long as they want to.

07:39So our plan is to give my CRISPR a year to make sure the telomerase change works,

07:44and then we'll do her.

07:48We'll aspirate a sample of your bone marrow.

07:50See if we can figure out what the hell you did.

08:00Hey, um, I don't think coffee's a good idea.

08:05Entire civilizations rely on it,

08:07but I don't think you're referring to the beverage itself.

08:09I don't think it's a good idea for first years and fourth years to go out.

08:12I'm bound to supervise you at some point in the future,

08:15and it'll get complicated trying to change dates out.

08:18And the fact is,

08:21seeing somebody you work with rarely ends happily,

08:24so I appreciate you thinking of me.

08:26I thought it was a date.

08:29I'm still new here,

08:31but I thought it was a good opportunity to get to know each other.

08:34Well, coffee's perfect because you're asking the least amount of commitment from another human being.

08:39It's not even lunch.

08:42If it's still a no, it's still a no.

08:44But I'll let you rethink your answer.

08:59He only claimed it wasn't a date to save face.

09:02Or maybe I just assumed.

09:05But why did I assume?

09:06I don't think I'm some kind of narcissist who thinks every man wants to get close to me.

09:11Or we both assumed it's a date because it's a date.

09:15This is fun.

09:16I like being your bestie.

09:17Slumber party?

09:24I made a poll to test the popularity of shower sex.

09:27I heard.

09:28I feel like I have some questions about that.

09:31Approved has one,

09:33but don't get too excited, Leah.

09:35It's only 58.38 with several complicated non-committals.

09:40So clearly my attitude is reasonable.

09:42We don't have room for a skier exercise thing.

09:47I'm only putting it together so I can take a picture and sell it online.

09:51Why do you have it if you don't want it?

09:53My ex sent it.

10:03Ex?

10:05Husband.

10:08I left this thing in the attic until I got settled somewhere with enough space.

10:12And okay, that was 10 years ago, but it's not like it was in his way.

10:19We got married.

10:21Not for long.

10:22Right out of high school.

10:24Literally the boy next door.

10:25We grew up together.

10:26People expected it.

10:27It was a big mistake.

10:31We both realized it pretty quickly.

10:37Why would you even want to live forever?

10:40You'd be bored out of your mind.

10:42The person I am now is miles away from the person I was at 14.

10:48I only get more distant every year.

10:51You learn to understand and love books that you once hated.

10:59Sometimes people you once hated.

11:02Music that you didn't get the point of becomes magical.

11:06A thousand new doors will open.

11:08I look forward to the adventure.

11:12Sorry, adventure's not always going to be fun.

11:15I figure it takes 40 or 50 years just to get over the things your parents did.

11:21If only we lived long enough, the human race might finally have a chance to grow up.

11:33What size shoes do you wear?

11:36Seven and a half.

11:38Dr. Allen's walking on clouds inserts.

11:40Putting Dr. in names always good marketing advice.

11:43Putting Dr. in names always good marketing strategy.

11:45They're designed to reduce inflammation that can lead to plantar fasciitis,

11:50calluses, arthritis, and they feel damn good.

11:53Does this have anything to do with our patient's venture capitalist husband?

11:56I need testimonials.

11:57Labs and path for Hannah Palmer.

12:02Aren't we all busy enough learning how to be surgeons?

12:05Do you really want to divide your focus onto something trivial?

12:13Because wanting to make money taints the purity of medicine?

12:18I have five brothers.

12:19I've been taking care of people my whole life.

12:22Someone got hurt, it came to me to patch them up.

12:25I became a doctor so I could get paid for it.

12:29But also because I'm good at taking care of people.

12:32It's possible to do something for more than one reason.

12:44The news is bad.

12:56There's an abnormally healthy population of hematopoietic progenitor stem cells.

13:03He did it?

13:04It's significant.

13:05He's succeeded in optimizing enough telomerase activity

13:08to potentially add 10 years to his natural life.

13:11Well, assuming he doesn't subtract about 50,

13:13there's already an autoimmune reaction that mimics Hirschsprung's.

13:16Who knows what else he did?

13:17What if this is the opposite of an autoimmune condition?

13:20What if he's done something that lowers his resistance to infection?

13:23Then we'd be seeing more opportunistic infections of the lungs and skin.

13:27If you lived another thousand years,

13:28would you be with the same person at the end as at the beginning?

13:32No.

13:35No, if you assume monogamy.

13:36I mean, that puts too much strain on a relationship.

13:38Is one person supposed to be everything to another all the time for a thousand years?

13:42Apparently Jesus agrees on monogamy.

13:46He said that in heaven there'll be no more marriages.

13:48I guess humans can't sustain a relationship that long.

13:52You read the New Testament too?

13:53And the Quran and other things.

13:56It's like you're a stalker.

13:57It's like you and God had an acrimonious divorce.

14:00What if he caused neurofibromatosis?

14:03Microscopic tumors forming on the nerve sheath?

14:06Impossible.

14:06But there'd have been some evidence of Schwann cell growth around his colon.

14:09Would you still love your wife in a thousand years?

14:14You have three answers.

14:15That should be enough.

14:16Hark's marriage failed in far less time.

14:18And Enrique doesn't even try.

14:20Asher is a unknown quantity.

14:23You're committed.

14:25You've made promises.

14:29I've made promises based on an understood human lifespan, Murphy.

14:34Most likely diagnosis is autoimmune polyneuropathy.

14:37It damaged the entroganglion nerve and led to the perforation.

14:40Stardom on steroids and immunosuppressants.

14:42Dr. Andrews, so you wouldn't have gotten married if you thought it would be forever.

14:48You expect all relationships to fail over time.

14:50It's just a question of how long.

14:54I love her now.

14:56I intend to love her as long as I live.

15:00But eventually, everything breaks.

15:14I always go back to comfort reading when I'm in the hospital.

15:16Cozy mysteries in little English villages where nothing bad happens to anyone we like.

15:22We've gotten your results back.

15:24When will your husband be-

15:25Is it cancer?

15:26Yes.

15:30Thyroid carcinoma.

15:32We're going to do a complete imaging series to pinpoint just how advanced-

15:36Treatment?

15:38Surgery.

15:39To remove some or all of your thyroid is usually the first line of defense.

15:43Sometimes we can wait, but given the hematoma was probably caused by the tumor invading nearby

15:48vasculatures, we should probably do it in the next few days.

15:52Later, they'll be radioactive iodine treatment.

15:54Panic attack?

16:04Her trachea's deviated to the right, the tumor's compressing it, we're doing surgery now!

16:22What happened? The nurse just said surgery. Was it the hematoma?

16:28It's more serious.

16:32It's not cancer, again.

16:36Thyroid carcinoma.

16:38We've removed her thyroid, she's doing well.

16:41We're looking into potential causes.

16:43Genetic, environmental, there may be a deeper issue that we can find and address.

16:52I can't do this.

16:56You've done it before.

16:59You'll do it this time.

17:06You know what it's like to wake up every morning and know your wife might not be here next year?

17:13All those years.

17:15To wake up every morning and know your wife might not be here next year.

17:20All those treatments, they all have this little tag attached to them that says because she might die.

17:30When you see them put those gloves on before they hook up the chemo, you know why they do that?

17:38It's because it's poison.

17:39You sit there, and you watch them shove poison into the person you love, and why?

17:50Because she might die.

17:54We're killing her because she might die.

18:02Go for a run. Go punch a wall.

18:06You know what it's like to wake up every morning and know your wife might not be here next year?

18:09You need to release some endorphins.

18:10My release is my job.

18:12That's why I love it.

18:14My work requires total focus, and every minute I'm working is a minute I'm not thinking about losing her.

18:28I have to go.

18:29Your pain and weakness are consistent with polyneuropathy, treatable with steroids and immunosuppressants.

18:41If you live a thousand years, will you still love Sophie?

18:47Yes.

18:48How can you be sure? People change. You expect to change.

18:53Sophie and I will change together.

18:56We'll go through the same adventures and learn the same lessons.

18:58What if you go through the same adventures and learn different lessons?

19:02Even if we did, whoever, whatever we become, Sophie will always be beautiful.

19:07I mean, she could turn into a machine or a set of pixels or a giant purple flower.

19:11She'll still be beautiful because it's part of her essential nature.

19:19But if you don't know how you'll change, you don't know how you'll change.

19:23Sean, we'll let you get some rest. The steroids should make you feel a lot better.

19:36Why didn't you ever mention you had an ex-husband?

19:40Sean, I've barely thought about him in years. I didn't mention him because he's not important.

19:48I know that's the problem. At one time, you felt he was important enough to your life

19:53to marry him, and now you barely think of him. You make long-term plans.

20:00You have expectations, and then something happens to you, and suddenly you're a different person.

20:07I know you don't like change, but it's not all bad.

20:12After all, you are working to change yourself all the time.

20:16I'm working to be a better surgeon, a better boyfriend, better at the things I've chosen.

20:24But this other change, it's unpredictable. You don't choose it. It just comes at you.

20:32It's like hurricanes before 1873 when the Army Signal Corps first put up flags to warn people

20:36storms were coming. Before that, houses were flattened, lives destroyed, and there was no

20:40way to see it was heading for you.

20:43Sean, our relationship will not end in natural disaster.

20:50It did begin in one.

20:54I'm going to look in on my patient.

21:06Blood and saliva will tell us if there is a genetic cause, and the samples we take from

21:11your house will tell us if there's something environmental.

21:15I know it's stupid. I've almost felt guilty for my cancer, like I arbitrarily

21:23decided to be sick and burdensome.

21:28Do the people you're close to ever act like you're a burden to them?

21:32You mean Alan?

21:36He's scared. He takes the exit he's got and he turns to his work. You're okay with that?

21:52I accept this compromise. That's not the hard part. The hard part is

21:56not knowing. Each new thing that happens, I worry, is this it? Is this where I lose him?

22:08Is this where he breaks?

22:17So this is boiled coffee.

22:20Some people call it Turkish coffee, or Greek coffee, or Egyptian coffee, because we need

22:25to take ownership and put things in categories. Yeah. So you actually live in this thing?

22:31In the hospital parking garage? Why not? Convenient for work,

22:35when I want to spend a few days off the beaten track. Convenient for that too.

22:40Ooh, I might get three sips in this. But three really great sips.

22:46That's how I try to live my life. Try to appreciate, savor, not pass by.

22:56Is that what the polyamory is about?

22:59Does it really work, or is it one of those theories about life that people regret later?

23:04No regrets so far. No, I guess not. Not while you're young and having fun.

23:10It is fun, but not for the reasons that you're thinking. It isn't about sex.

23:15It's about commitment. Emotional connection. The joy I'm sure you get out of a relationship,

23:20I get a little more. Also, I have to give a little more. But that's meaningful too.

23:26Do you mind if I ask you something, since we're getting personal?

23:36Sure. What's your favorite misheard song lyric?

23:49This is nice.

23:50I'm glad it's not a date. Me too. I don't believe in those categories.

24:02He reported widespread bilateral pain, then he keeled over. BP dropped to 80 over pound.

24:06I'll order a vasopressor. Already did.

24:08Good. We need an EKG, CBC, and chest images, and a new diagnosis.

24:13Whatever he calls with CRISPR, it's not just neuropathy. Something else is killing him.

24:20What if he's caused something that mimics carcinomatous autonomic neuropathy?

24:29Explains the BP and bowel issue.

24:32That doesn't explain the sensory issue that led to the frostbite.

24:38A connective tissue disorder?

24:40That would have shown up on the scans. His chest looks normal.

24:43Maybe we can't think of the answer because there is no answer.

24:46We keep trying to jam it into these categories we know, the diseases that we know.

24:49But this never existed before.

24:52He created a new combination of genetic code that means a new combination of symptoms.

24:56So we shouldn't be looking at what fits the picture, but at what's closest to the picture,

25:00so we can at least figure out a treatment.

25:02And what it's closest to is amyloidosis. This isn't an autoimmune neuropathy.

25:08So the nerves must be under attack by something else.

25:10Something like amyloid disease could leave deposits along the nerves,

25:13causing the symptoms we've seen.

25:15Where do we look for those deposits?

25:18Explain.

25:26Drink all eight ounces.

25:28We talked. We had a few laughs.

25:30That sounds date-y to me.

25:33I don't think Enrique's a bad guy.

25:35Sounds date-y to me.

25:37I don't think Enrique's a player.

25:39He's kind of the opposite of a player. With him, emotional connection is the point.

25:43He's trying to live some idealistic fantasy where everyone is nice and no one is jealous.

25:47I am so staying away.

25:49Well, of course. Once I heard emotional connection, I knew the game was over.

25:53What does that mean? I'm against emotion?

25:56I'm not the one with cold-hearted bitches, my social media hashtag.

26:00She's an excellent doctor.

26:01Every time you've loved somebody, it's ended in disappointment or death.

26:04Sometimes both.

26:05It's like a reflex now.

26:07You just expect that everything ends badly, so why start?

26:10So despite the many practical reasons not to go out with the first year, this is all about me.

26:16Is that a diamond ring?

26:19It's pretty.

26:20Impatient caught her fiancé cheating.

26:22Big fight. He demanded the ring back.

26:24She swallowed it.

26:25I did.

26:26You don't even know if this is going out, and that's the point.

26:29It doesn't matter what Enrique's offering,

26:31whether it's friendship or romance, you're not investing.

26:34You're risk-averse.

26:35Your portfolio right now is entirely in T-bills and money market.

26:38I have no idea what that means.

26:39And it's too bad, because a guy that can make you laugh might be just what you need right now.

26:44It's regressed your large intestine.

26:45Here's a plastic bag. Put it over the toilet seat.

26:48You'll have every opportunity to recover your property.

26:54Don't run away from a chance at love.

26:58It's a date.

27:01Maybe. I don't know.

27:04Her house is full of TCE.

27:07Side effect from chip-making back in Silicon Valley's early days.

27:10So they move away from their toxic home, and hopefully things get a little better.

27:13Probably not much.

27:14She also has a genetic predisposition.

27:16It's both.

27:18She shouldn't go outside in a rainstorm.

27:22How do you tell a woman that her third cancer likely won't be close to her last?

27:28Unfortunately, this is a teaching moment.

27:34Dr. Allen, after 12 hours on duty, I can report that your inserts came through.

27:40Check your email. You'll find my testimonial.

27:43Claire, Olivia.

27:52And if you're right, what will you do?

27:55We'll treat the symptoms with targeted drug therapies.

27:58There really isn't a disease as such that we can address.

28:04The pain shifted?

28:09Yeah.

28:11Never mind about the ultrasound.

28:12It'll be easier to check for deposits after the organ's been removed.

28:15After it's...

28:16Yeah, his spleen's about to rupture.

28:17Call the transport team.

28:30It's called Li-Fraumeni syndrome, LFS.

28:33An inherited predisposition to developing a wide range of cancers.

28:37Yes, there was a toxin in your environment that likely played a role in this,

28:41but there will be other triggers in the future.

28:44Your body is super sensitive and will respond with tumors for the rest of your life.

28:56I know that's a shock, but here's what you should know.

29:00Most cancers are treatable if found early enough.

29:07We know the most common associated with LFS,

29:10and we can do surveillance,

29:12nip anything in the bud before it becomes a problem.

29:17It may not seem this way now, but this is good.

29:21We know what we're dealing with.

29:23We're warned, and we'll be ready.

29:30He won't be able to handle this.

29:38Liver, pancreas, other organs look normal.

29:42But there are calcified lesions along these nerves.

29:45He's going to be in pain like this for the rest of his life.

29:47No, there's a reasonable chance it'll get worse as time goes on.

29:52I need my sharp, blunt, curved scissors.

29:54What if we use CRISPR to reverse this?

29:56I need my sharp, blunt, curved scissors.

29:58What if we use CRISPR to reverse CRISPR?

30:02Researchers have identified a protein in certain bacteria that inhibits CRISPR.

30:07What if we insert the DNA that makes that protein into our patient's genome?

30:11That would deactivate the CRISPR gene.

30:12So CRISPR messed him up permanently, and you think we should do more of it?

30:16Our patient is a risk taker.

30:17We need a delivery mechanism.

30:19The code would have to be introduced to a virus.

30:22A virus that specifically targets nerves.

30:26Polio targets nerves.

30:28Because this isn't risky enough.

30:30Polio is such a dangerous virus because it's so good at penetrating.

30:52Dr. Murphy?

30:57She's going to be this way forever.

31:02She'll have good periods and bad periods.

31:05But she will always have to be on our guard.

31:09Is she always going to have to be on guard against you, too?

31:13What does that mean?

31:14Chronic illness puts strain on relationships.

31:17Statistically, it is more often the man who can't handle it.

31:20Our marriage is none of your business.

31:23Her health is my business.

31:24And your behavior adds to her stress.

31:29You look at her.

31:30You imagine she's gone.

31:32And that is hard.

31:33I get it.

31:36She thinks the same thing when she looks at you.

31:40I never complain to her.

31:42I know it's nobody's fault.

31:43You don't think she knows you have trouble with all this?

31:46Every time something new happens, she wonders,

31:49is this the straw that is going to break your marriage?

31:54You've got her living in a constant state of uncertainty.

31:57That is practically the definition of stress.

32:01So this is the straighten up and fly right lecture?

32:05No.

32:08I am telling you to consider how best to time your divorce.

32:17There are going to be a lot of new issues dropping on Hannah.

32:20And if you're going to end up leaving anyway,

32:22you should start planning now.

32:23I don't want to leave my wife.

32:24My best advice?

32:27Help her through this next round of treatment as best you can.

32:31And then get out.

32:34It's hard living with someone who needs so much.

32:38I know you feel there is a point where you have nothing left.

32:42But you're ready to break.

32:45Just don't break when she needs you most.

32:51Get out before that happens.

32:54Okay.

33:14Reading an article that's five years old?

33:16Dr. Glassman was once involved in an experimental attempt

33:19to treat Parkinson's with CRISPR technology.

33:22It failed.

33:23So it's both old and it didn't work.

33:25Dr. Glassman likes his failures to be informative.

33:28That's why his articles are longer.

33:30Do you worry about losing the people you love?

33:38Because we can't stop ourselves from changing,

33:41which means we might stop loving someone

33:43or they might stop loving us.

33:45It is a very bad thing.

33:48It is.

33:49So, no one can ever feel safe.

33:53How can you keep going if you never feel safe?

34:01Well, sometimes not changing is just as dangerous.

34:07So how do you know when to do what?

34:13If you find the answer to that, let me know.

34:16I have it.

34:17You do?

34:18Dr. Glassman used Ferrocell Azoster virus

34:20as the delivery mechanism, which didn't work.

34:23His first choice was herpes simplex,

34:25but the technology was not up to putting their DNA package into it.

34:29The technology has improved.

34:31It can be done.

34:37I'm sorry, I didn't mean to interrupt.

34:39I'm sorry, I didn't mean to interrupt.

34:41I'm sorry, I didn't mean to interrupt.

34:44You can't.

34:48Using conventional treatments there's nothing more we can do for you.

34:51The pain will be permanent and it could get worse.

34:56I've not been one to be limited by the conventional.

35:01We think we can reverse the CRISPR.

35:03You want to reverse what I did?

35:04My telomerase changed?

35:06They want to stop your pain.

35:07Soph, it's temporary.

35:09What is it, 40 years?

35:10That's nothing.

35:11Our real lives.

35:12They're ahead of us.

35:14Okay, look, as long as this doesn't kill me,

35:16I've made the right choice no matter how bad things get.

35:19No.

35:22I was willing to exercise for hours and fast,

35:26to give up all sugar and alcohol

35:29and do all the other things that we needed to do

35:31to get to a future that I knew might never come.

35:35Wow.

35:36But now you're asking me to watch you suffer

35:40for the rest of your life.

35:51You're the one who embraces change.

35:55So change to the person who can be happy with me

36:01here and now.

36:11Doctors, would you mind waiting outside?

36:20Why did she want us to leave?

36:23I think she's delivering an ultimatum.

36:35For the last time,

36:38are you sure about this?

36:41It seems there's always something else

36:43that I have to give up.

36:47But this isn't like sugar or cigarettes.

36:50You won't get over this in a hurry.

36:53No.

36:55Not in a thousand years.

36:59And the way we talked last night

37:07Are you gonna be okay?

37:09I'm fine.

37:10Alan's at work, but there should be a taxi waiting.

37:13I won't say goodbye, Dr. Brown,

37:16because I'll probably be seeing you again pretty soon.

37:22I sent your cab away.

37:25I'm sorry I wasn't here sooner.

37:28I had to present a proposal to my partners.

37:39I'm selling them my share of the business.

37:45Is there something else you want to do?

37:49Yes.

37:52I want to be your husband.

38:01I realized

38:03I was so afraid of losing you in the future.

38:11I'm losing you now.

38:22I love you.

38:40Sorry.

38:42I hear your VC contact decided to quit the business.

38:47He did the right thing.

38:53You know,

38:56my feet are killing me.

39:23I'm open to being friends.

39:27That's great. I'm open, too, to whoever this goes.

39:31It's going to friendship.

39:34Understood.

39:36But life is about change, which means one day you might change your mind,

39:39and if you did, I'd be open to that, too.

39:42It's not gonna happen.

39:46Okay.

39:53One.

39:56Two.

39:59Three.

40:07First, there should be no soap involved.

40:10Also, we need to stay at one end of the shower

40:12so we don't accidentally knock into the temperature control.

40:15What changed your mind?

40:18I've been thinking about change over time.

40:21I spoke with people and also graphed several possibilities for us

40:24using time as the horizontal axis and change as the vertical.

40:27I realized that the problem isn't really change.

40:30It's whether two people change in the same direction.

40:34We want to keep our coordinates close to each other for the rest of our lives.

40:40We certainly do.

40:43But people do sometimes drift apart.

40:46Yes, you need a warning when you and your partner

40:49might be starting to veer off so you can both change course a little.

40:52You don't want a surprise realization when it's too late.

40:55Surprises are awful.

40:57The U.S. Army Signal Corps used flags to warn of hurricanes.

41:00I brought us this.

41:03A cowbell?

41:05If you see us heading in different directions, you ring it.

41:09Do we really need a bell? Can't I just tell you?

41:12When you ring it, I'll pay attention.

41:15I really hate the sound.

41:18Only in emergencies.

41:21I've already moved the shampoo bottles.

41:24What?

41:27Oh.

41:30You mean now?

41:35Don't worry about putting the bottles back. I'll do it later.

41:38I love you.

41:41It's no trouble. I remember where they all go.

41:48I love you.

41:51I love you.

41:54I love you.

41:57I love you.

42:00I love you.

42:03I love you.

42:06I love you.

42:09I love you.

42:12I love you.

42:15I love you.

42:18I love you.

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