World IVF Day 2025: What Happens When IVF Fails? Expert Advice On Next Steps And Emotional Recovery

ETVBHARAT

One should have realistic expectations when they start an IVF cycle. It’s a scientific process. It can’t be 100% successful today

Transcript

00:00Today we are going to talk about a topic which is much neglected.

00:06Everybody talks about how to improve success and how to deal with a specific situation.

00:12But then at the end of the day there is a subset of couples where success doesn't come.

00:17And they are left in an emotional lurch.

00:21So how do they deal with it and what to do further to improve their prognosis

00:26and they help them in achieving the goal that they set out to.

00:31So first of all I would say that one should have realistic expectation when they start an IVF cycle.

00:38Because no matter how much ever we try to make it successful it's a scientific process.

00:45So it can't be a 100% successful procedure today.

00:49Because the process of reproduction being very very complex.

00:52We are still as the entire IVF fraternity worldwide.

00:56We are in the process of learning it, discovering more about it.

01:00And trying to solve the problems which can come, which can interfere with reproduction.

01:06So the emotional part has to be dealt with patience and realistic expectations.

01:13If needed please go for counselling and understand what exactly is the problem.

01:19And what are your chances, what are the options available.

01:22So once your cycle turns negative, once you are out of the initial shock.

01:27Please visit your doctor.

01:29Discuss the details about what happened exactly during your last IVF cycle.

01:34And what looks like the probable cause.

01:38It is very difficult to point out the exact cause why an IVF cycle didn't work.

01:42But your doctor will be able to give you some idea.

01:45Because of the progressive learning that we get while we conduct a couple's IVF cycle.

01:51We understand that this could be the problematic area.

01:54And if there is a next time then we can work more on it.

01:58So for example if you have done a fresh cycle and you still have frozen embryos remaining with the clinic.

02:04You can opt for a frozen embryo transfer cycle as your next attempt.

02:09If you have frozen embryos.

02:10In that case if endometrial development had not been optimized or some new findings had come.

02:16Then that has to be optimized.

02:18If required a histoscopy can be done to get a better idea of the uterine cavity.

02:22If required a biopsy can be done.

02:25Sometimes when there are very subtle issues.

02:28There are some experimental tests like error that also can be done.

02:32Then say for example if the couple is in the higher age bracket.

02:37Or if there is a history of miscarriage.

02:39If the indication is there.

02:41Then some more optimization can be done by testing the embryo.

02:45Whether it is normal genetically.

02:47For example aneuploidy testing.

02:49Pre-implantation genetic diagnosis is the term for that.

02:52And time the transfer better.

02:55Then at the same time there are some therapies which are not proven very clearly.

03:00But they are considered a good practice.

03:03Say for example if there is a recurrent implantation failure.

03:06Then sometimes there is a use of heparin injection.

03:09No molecular with heparin or aspirin.

03:12Which are known to help in implantation.

03:14There are more therapies.

03:16But because convincing data is lacking.

03:19So some people are using it.

03:22But that cannot be given as a blanket treatment for all couples.

03:27So essentially it is about finding out what are the probable causes.

03:31What learning has come from the last cycle.

03:34And then how can we optimize it.

03:36Say for example if getting the egg number or quality was the issue.

03:41And if this appears to be a recurrent problem.

03:44If the lady is on the higher age bracket.

03:46Then consider maybe using donor eggs.

03:50Then if there is a say for example some problem with the uterine cavity.

03:56That has to be corrected.

03:57At the same time while you are undergoing your next cycle of fertility.

04:01All the time you have to be in touch with your counsellor.

04:07And you need to have very good support system.

04:10Both in the family as well as in the clinic.

04:12So any clinic worth it sort.

04:14Any IVF clinic will have that support system available.

04:17Which is just a phone call away.

04:19Whenever you feel stressed out.

04:21There are lots of things to be done in the embryology lab.

04:24Apart from trying to create the best possible embryo for the couple.

04:27There are some experimental therapies for example.

04:31Co-culture.

04:32So lots of other things are there.

04:34So there some improvisation could be possible.

04:37So all of it can help a couple.

04:39Which has not conceived in their first attempt of IVF.

04:42So in subsequent attempt we can of course try and increase their chances.

04:49To be continued.

04:51To be continued.

04:52To be continued.

04:53To be continued.

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