Vijayalakshmi debuted in the 2007 film Chennai 600028 under the direction of Venkat Prabhu. The film was eventually a blockbuster and she later portrayed the female lead role in the film Anjathe which was also a critically acclaimed film. After making a special appearance in Venkat Prabhu's Saroja in 2008, she worked in Adhe Neram Adhe Idam.