Hydroxychloroquine, evidence of efficacy

Belgium, not Dutch. Low-dose Hydroxychloroquine Therapy and Mortality in Hospitalized Patients with COVID-19: A Nationwide Observational Study of 8075 Participants (International Journal of Antimicrobial Agents, 24 August)

https://www.sciencedirect.com/science...

Background

Hydroxychloroquine (HCQ) has been largely used and investigated as therapy of COVID-19 , at total dose usually ranging from 2400 mg to 9600 mg.

In Belgium, off-label use of low-dose HCQ (2400 mg in total over five days) was recommended for hospitalized patients with COVID-19.

“low-dose” regimen of HCQ sulphate in monotherapy

400mg twice on day 1

200mg twice a day from day 2 to 5

i.e. a total dose of 2400 mg

Methods

Multi-centric design

Vast majority of Belgian hospitals

Retrospective analysis

In-hospital mortality in Belgium

40 day follow up

No difference in the baseline characteristics

Groups

HCQ alone and supportive care

Supportive care only

Adjusted for demographic and clinical features

Results

8075 patients with complete discharge data

HCQ group, n = 4,542

Deaths, 804, (17.7%)

no-HCQ group, n = 3,533

Deaths, 957 (27.1%)

Multivariable analysis

Mortality was lower in the HCQ group compared to the no-HCQ group

Hazard ratio = 0.684

Estimated direct-adjusted mortality at 40 days

19.1% with HCQ alone

26.5% with supportive care only

Mortality in the HCQ group was reduced

Both in patients diagnosed in less than 5 days and more than 5 days

Conclusions

Compared to supportive care only, low-dose HCQ monotherapy was independently associated with lower mortality in hospitalized patients with COVID-19 diagnosed and treated early or later after symptom onset.

To any Doctor, Hospital or ER that thinks they can survive a lawsuit for not provided the option of HCQ in their treatment options to the Covid19 patient, here is the list of papers that could and probably should be presented indicating that as an institution you had a duty of care to be aware of the potential for HCQ to save the lives of Covid19 patients that present to your establishment:

http://tribeqr.com/v/hcqefficacydailyupdates


To any Governor, Premier, law maker, Media Outlet or forum, Authority overseeing the availability of medications or similar that is party to obstructing the availability of HCQ for the responsible prescription of a Doctor - a Doctor that was formerly qualified to prescribe HCQ and no longer able to because of in part or in full that party-, here is the list of papers that could and probably should be presented indicating that as a institution or individual you had a duty of care to be aware of the potential for HCQ to save the lives of Covid19 patients and that your actions for removing this potentially life saving medication with no just cause is in part or in full responsible for the suffering or death of Covid19 patients and or their friends and family.

http://tribeqr.com/v/hcqefficacydailyupdates