Millions affected, few treatments. NANOSPRESSO is changing the narrative for rare diseases with on-demand, personalized therapies. The future of medicine is here. Learn how NANOSPRESSO's innovative approach is decentralizing drug manufacturing and bringing cutting-edge treatments to the patient's bedside. From complex labs to hospital pharmacies, personalized nanomedicines are becoming a reality. NANOSPRESSO is leading the charge in accessible, tailored healthcare solutions. #FutureofHealthcare #MedicalBreakthrough #RareDiseaseHope
02:09With this coffee machine, a hospital pharmacist can instantly and personally brew a nanomedicine espresso for each patient,
02:17precisely calibrated with the exact instructions their body requires.
02:21This radically diverges from large coffee factories that produce millions of the same blend for a global market.
02:27In this transformative way, even individuals with a highly uncommon taste and orphan disease
02:33can have their bespoke coffee, fresh and readily available, precisely when and where they need it.
02:40Although the article does not delve into specific applications of nanospresso for neurodegenerative diseases,
02:46it unequivocally highlights the significant potential of the underlying nucleic acid therapeutic technology in this field.
02:52For instance, this technology has been successfully employed to silence the production of pathogenic proteins
02:59in conditions like hereditary transthyrotin, amyloidosis, which often presents with neurological manifestations.
03:06In fact, the already approved drug patisium, which utilizes lipid nanoparticles to deliver a small interfering RNA,
03:13is currently used for this very condition.
03:15Despite their immense potential for personalized medicine, these treatments have faced significant roadblocks,
03:22including prohibitive costs, complex manufacturing processes, a lack of commercial incentives for rare diseases,
03:29and formidable challenges in approval and reimbursement procedures.
03:33Given nanospresso's versatile platform for the customized production of nucleic acid nanomedicines,
03:39its ability to create personalized treatments directly at the point of care could dramatically accelerate access to these vital therapies.
03:47This includes a broad spectrum of neurodegenerative conditions caused by genetic anomalies or protein dysregulation.
03:54The project envisions that this design flexibility could extend beyond orphan diseases,
03:59encompassing personalized oncology, and even the fight against emerging pathogens.
04:04It's comparable to owning an extraordinary race car, but encountering an exorbitant price tag and a scarcity of fueling stations.
04:12They also allow for the creation of highly adaptable vaccines,
04:15as evidenced by the mRNA vaccines developed against various COVID-19 variants.
04:20These are like master keys precisely crafted for specific locks within our cells.
04:25They are large, negatively charged, and incredibly delicate molecules,
04:29making it exceedingly difficult to get them inside our cells,
04:32which are protected by a nearly impenetrable membrane.
04:36The tragic reality is that, due to their rarity, treatment options are scarce, if they exist at all,
04:42nucleic acids, while varying in their specific sequence and length.
04:46Effectively, the instructions they carry possess a fundamentally similar molecular nature.
04:52This inherent characteristic makes them exceptionally well-suited for personalized production.
04:57Based on technological platforms within local hospital pharmacies,
05:00this revolutionary approach enables the creation of a unique treatment tailored precisely to the individual needs of each patient,
05:07directly at the point of care.
05:09Its core mission is to democratize access to personalized treatments for rare diseases and other conditions,
05:16making them both accessible and affordable for healthcare systems globally.
05:19Nanospresso proposes a fundamental shift in paradigm by decentralizing the production of nucleic acid-based nanomedicine.
05:27Instead of relying on massive centralized factories,
05:31the Nanospresso model allows hospital pharmacists to assemble tailor-made treatments directly within the hospital,
05:37even right at the patient's bedside.
05:39This void is primarily due to a lack of commercial incentive for pharmaceutical companies to invest billions in drug development for such small markets,
05:48further complicated by high costs, intricate manufacturing processes, and stringent regulatory requirements.
05:55But a groundbreaking solution is emerging from the realm of nanomedicine,
05:59a scientific discipline that operates at an incredibly minute scale.
06:02The main hurdle for these nucleic acid therapeutics has been their delivery.
06:07This is the critical juncture where the Nanospresso project,
06:10aptly named to evoke the convenience of brewing coffee at home,
06:14enters the scene as an innovative answer to these challenges.
06:17This remarkable capability is achieved through the seamless integration of advanced microfluidics,
06:22a technology that enables the incredibly precise mixing of liquids in minuscule channels
