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00:00The origin of modern humans remains one of the most complex and debated topics in paleoanthropology.
00:12During the middle to late Pleistocene period, our ancestors shared the planet with multiple other human species across Africa and Eurasia,
00:21creating a fascinating mosaic of human diversity.
00:25These included the Neanderthals in Europe, the Denisovans in Asia, the small-brained but sophisticated Homo naledi in South Africa,
00:33the diminutive hobbits or Homo floresiensis in Indonesia, and the recently discovered Homo luzonensis in the Philippines.
00:41This period represents the last time Earth was home to multiple human species before Homo sapiens became the sole survivor.
00:49The relationships between these groups, who evolved from whom, who interbred and who went extinct, continue to challenge scientists as new discoveries emerge.
01:00Asia, in particular, presents a crucial yet puzzling piece of the story of human origins.
01:05Fossils discovered across Asia, including the Namada, Maba, Dali, Jinyushan, Xuchang, Habin, and Hualongdong specimens,
01:15provide crucial insights into human evolution during the middle to late Pleistocene.
01:21However, poor preservation of these fossils and interpretations influenced by regional continuity theories
01:27have made it difficult to place them accurately in human evolutionary history.
01:31The Namada fossil, discovered in the Namada valley of Madhya Pradesh, India, is considered either a late Homo erectus or an archaic Homo sapiens,
01:41and is an important hominin finds in South Asia.
01:45In China, several key fossil sites have yielded remains with a mosaic of archaic and modern features.
01:51The Maba skull from Guangdong province shows intermediate traits between Homo erectus and Homo sapiens.
01:56The Dali cranium from Shanxi and the Jinyushan fossil from Liaoning both reflect transitional forms,
02:04often attributed to Homo heidelbergensis or early Homo sapiens, dating to approximately 200,000 to 260,000 years ago.
02:13The Xuchang fossils from Henan province display a combination of traits linked to both archaic humans and possible Denisovan lineage,
02:21while the Hualongdong fossils in Anhui province, dating to around 300,000 years ago,
02:28show a unique mix of primitive and modern anatomical features.
02:32Together, these discoveries highlight the complex evolutionary landscape of early humans across Asia
02:37and their importance for understanding the emergence of Homo sapiens.
02:42Among these, the Harbin cranium stands out as the most complete and best preserved.
02:47Because of its unique combination of ancient and modern traits,
02:52scientists have proposed that it belongs to a new human species named Homo longi.
02:57The species name longi comes from the Chinese term longjiang, which means dragon river,
03:03a poetic name for the Heilongjiang province, where the fossil was found.
03:07The skull was discovered near Dongjiang Bridge in Harbin City
03:10and was later donated to the Geoscience Museum at Hebei Geo University in 2018.
03:15The fossil was dated to about 146,000 years old, placing it in the late Middle Pleistocene period.
03:24What makes Homo longi unique is its combination of features.
03:29The skull is massive, larger than those of most known ancient humans.
03:33It has a large brain capacity, 1420 milliliters, similar to modern humans and Neanderthals,
03:41but the shape of the brain case is long and low, not round like ours.
03:47The brow ridges are thick and heavy, the face is wide but flat, and the eye sockets are large and square.
03:54The nose is broad, and the jaw region suggests the presence of large teeth, but without a chin.
04:02When compared to other fossil skulls from Asia and Europe, Homo longi shows clear differences.
04:09It lacks the thick bone structures of Homo erectus, the inflated cheeks of Neanderthals,
04:14and the sharply angled back of the skull seen in Homo heidelbergensis.
04:19It also differs from the Dali and Hualong dong skulls, which have their own distinct features.
04:26Because of this, scientists propose that Dali and Hualong dong belong to a different species,
04:32Homo daliensis, while Harbin represents a completely new one, Homo longi.
04:38Studies of ancient DNA from Middle Pleistocene sites in North Asia and Europe
04:43have proven invaluable in establishing the genetic relationships between early humans and modern populations.
04:50One of the key breakthroughs from this work was the discovery of a previously unknown archaic human population,
04:56the Denisovans, identified through DNA extracted from bones and teeth in Denisova Cave in Siberia.
05:04However, understanding Denisovan physical characteristics
05:07remains limited due to the fragmentary nature of the fossils,
05:12which offer little morphological information.
05:15Interestingly, the Harbin skull appears to be closely related to a jawbone found in Xiahei, China,
05:22which is believed to belong to the Denisovan lineage.
05:25This connection raises the possibility that the Harbin individual
05:29may have also been part of the Denisovan group, or a close relative.
05:34The Denisovans were an ancient human population
05:37that once roamed the Earth alongside the Neanderthals and modern Homo sapiens.
05:42However, nobody knew about them until a groundbreaking discovery in the Denisovan cave in Siberia.
05:50In 2010, an analysis of mitochondrial DNA extracted from a finger bone found in the Denisovan cave in the Russian Altai
05:59revealed the existence of a new hominin taxon.
06:02This newly described group was found to be genetically distinct from both Homo sapiens and Homo neanderthalensis.
06:10The mitochondrial DNA sequences showed haplotypes outside the range of variation of modern humans and Neanderthals.
06:19During the late middle to early upper Pleistocene, three distinct groups emerged.
06:25Early modern humans in Africa, Neanderthals in Europe, and Denisovans in Asia.
06:30Molecular data suggests that the split between Neanderthals and Denisovans occurred between 380,000 to 470,000 years ago,
06:40while the branch leading to Denisovans and modern humans diverged around 800,000 years ago.
06:47Homo heidelbergensis migrated to Eurasia around 800,000 years ago,
06:52as indicated by the sites in Israel in the Levant region.
06:57Around 450,000 to 350,000 years ago,
07:01Homo heidelbergensis from the Levant migrated to the Iranian plateau
07:05and further to Central and North Asia,
07:08including Denisova cave in southern Siberia, giving rise to Denisovans.
07:13This migration marked the splitting of late Homo heidelbergensis into Neanderthals and Denisovans.
07:19Moreover, late Homo heidelbergensis from the Levant
07:24also reached to regions such as Turkmenia, Kazakhstan, and Mongolia,
07:29as indicated by the appearance of Atulian industries in those areas.
07:33Their likely route was north of the Himalayas and Tibet.
07:36The mandible found in Baishia cave on the northeastern Tibetan plateau
07:40dates back to at least 160,000 years ago.
07:44The presence of Denisovans in the region is also supported by the adaptation of Tibetans
07:49to high altitudes, possibly through introgression from Denisovans.
07:55Hybridization events occurred between these groups,
07:58suggesting a metapopulation that includes all three taxa.
08:02The Altai region, where Denisova cave is located,
08:05was occupied by Neanderthals, Denisovans, and modern humans,
08:09although the precise timing and coexistence of these groups remain uncertain.
08:15The Denisovar-11 girl represents an example of first-generation hybridization
08:19between a Neanderthal mother and a Denisovan father.
08:23Although Denisovans likely lived across much of Asia,
08:26scientists have only found direct genetic evidence of them at a few places.
08:30These include Denisovar cave in Siberia,
08:33Baishia cave in Tibet,
08:35the Penghu channel near Taiwan,
08:37and possibly a site in Laos called Tam Nguhao-2,
08:41based on fossil shape.
08:43It's been difficult to clearly classify Denisovans,
08:46because very few complete bones or usable DNA samples have been found.
08:50For example, a jawbone from Baishia cave
08:53was linked to Denisovans using protein analysis,
08:56but no DNA has been recovered from it yet.
08:58Interestingly, fossils from Sima de los Huesos in Spain
09:03have mitochondrial DNA inherited from mothers similar to Denisovans,
09:08but their nuclear DNA, inherited from both parents,
09:12is closer to Neanderthals.
09:14This suggests a complicated family tree among ancient humans.
09:19Most of the information about Denisovans
09:21has been inferred based on analysis of modern human DNA.
09:25The genetic diversity observed within the Denisovan lineage
09:28suggests their deep divergence and separation
09:30into three distinct branches across different regions.
09:34The D0 lineage, often called the Altai Denisovan lineage,
09:38is the best studied,
09:40and the only one directly confirmed through ancient DNA sequencing.
09:44It originates from Denisovar cave in the Altai mountains of Siberia.
09:47Multiple fossil remains have been recovered from this cave
09:51and are attributed to this group, including
09:53Denisovar 2, a juvenile molar,
09:57genetically sequenced and dated to over 100,000 years ago.
10:01Denisovar 8, an adult molar,
10:04dated to around 120,000 years ago.
10:07Denisovar 19, 20, and 21
10:10show affinity to the older Altai Denisovan population
10:13and are dated to roughly 160,000 to 200,000 years ago.
10:18These individuals,
10:20Denisovar 2, 8, 19, 20, 21,
10:24represent the earlier and more divergent branch
10:27of Denisovans in the Altai region.
10:29By contrast, Denisovar 3, a distal finger bone,
10:33and Denisovar 4, another molar,
10:36are younger,
10:37dated to about 50,000 to 76,000 years ago,
10:40and show greater genetic similarity to Neanderthals,
10:43possibly due to increased admixture
10:45or regional variation over time.
10:48These fossils reflect the younger population
10:50of Denisovans in Denisovar cave
10:52and suggest that this site was occupied intermittently
10:55by genetically distinct Denisovan groups
10:57over tens of thousands of years.
11:00Despite the valuable DNA data,
11:02the D0 lineage shows minimal genetic contribution
11:05to modern human populations.
11:07This could mean the Altai Denisovans
11:09had limited contact with Homo sapiens
11:11or were geographically isolated in Siberia.
11:15Notably, Denisovar 11 also belongs to this lineage
11:18and reflects interactions between archaic groups
11:21rather than modern humans.
11:23The D1 Tibetan lineage
11:25is genetically inferred from introgressed Denisovan DNA
11:28in modern East Asian populations,
11:31particularly among Tibetans and Han Chinese.
11:34This lineage is distinct from the Altai Denisovans
11:37and is thought to have lived in mainland East Asia,
11:41especially in the Tibetan plateau.
11:44The strongest evidence for this lineage
11:45is the EPAS1 gene in Tibetans,
11:48which confers an advantage in high-altitude,
11:51low-oxygen environments.
11:53This gene's origin cannot be traced to the Altai Denisovans,
11:57confirming it stems from a different,
11:59diverged Denisovan population.
12:00The fossil likely associated with this lineage
12:03is the Baishia-caste cave mandible from Shahe, Tibet,
12:07dated to around 160,000 years ago.
12:10The D2 lineage, or Australopapuan Denisovans,
12:21also called Oceanan lineage,
12:23is based entirely on genetic introgression patterns
12:26found in modern Papuans,
12:28Aboriginal Australians and Melanesians,
12:30who carry up to 5% Denisovan ancestry,
12:35the highest known levels globally.
12:36This lineage is deeply diverged
12:39from both the Altai and East Asian Denisovans,
12:42suggesting a long-separated and possibly isolated population
12:46of Denisovans living in island Southeast Asia.
12:49Although no direct fossil evidence
12:51has yet been tied to the D2 lineage,
12:54it is possible that this group occupied parts of Wallasea
12:57or the Sunda Shelf Islands.
13:00Speculative links have been made to archaic fossils
13:03such as those at Nagandong, Java, or even Homo floresiensis on Flores,
13:09but no genetic data confirm a Denisovan identity.
13:12This lineage is thought to have interbred with Homo sapiens,
13:16migrating through Southeast Asia towards Sahu,
13:19prehistoric Australia and New Guinea,
13:21leaving a substantial genomic legacy in Oceanan peoples.
13:25The D3 lineage, Philippine Denisovans or Negrito lineage,
13:31is genetically inferred from indigenous Philippine populations,
13:35especially the Aita Macbukon of northern Luzon.
13:39These groups exhibit the highest known proportion of Denisovan DNA,
13:43surpassing even Papuans.
13:45The D3 lineage is deeply diverged from all other known Denisovan groups,
13:50implying a long, separate evolutionary trajectory,
13:53likely within the Philippine archipelago.
13:56The populations of eastern Indonesians, Papuans,
13:59Philippine Negritos, Siberians, South Asians and East Asians,
14:04are among the few existing groups that exhibit substantial traces
14:07of genetic material from Denisovans.
14:10It is worth noting that the region of islands Southeast Asia and Papua,
14:14which consists of numerous densely inhabited archipelagos,
14:18holds some of the earliest evidence of early archaic humans outside Africa.
14:22Additionally, it is believed that archaic hominins like Homo floresiensis
14:28coexisted with modern humans in this region.
14:31Modern Australian aboriginals and Papuans
14:33have the highest proportion of around 5-6% of Denisovan ancestry,
14:39while American and mainland Asian populations
14:41have a smaller proportion of about 0.2%.
14:44A possible fossil link to this lineage is Homo luzonensis,
14:49discovered in Kalao Cave, Luzon, and dated to at least 67,000 years ago.
14:55Though DNA could not be extracted,
14:57the fossil's primitive and unique features hint at regional evolution
15:01of a Denisovan-like population.
15:04The high Denisovan ancestry in present-day Negrito groups
15:07supports the idea that early Homo sapiens arriving in the Philippines
15:12interbred with an indigenous Denisovan population,
15:16forming the D3 lineage's legacy.
15:18The Harbin cranium, found in northeastern China,
15:21has been linked to the Denisovans through ancient DNA analysis.
15:26Although researchers couldn't extract DNA from the bone or tooth,
15:29they successfully retrieved it from dental calculus,
15:33hardened plaque on the teeth.
15:34Out of 20 DNA samples prepared,
15:387 contained Denisovan-specific genetic markers,
15:41and none had Neanderthal markers,
15:44pointing to a Denisovan connection.
15:46To avoid bias,
15:47scientists compared the Harbin DNA not just to modern humans,
15:51but to a broad ancestral DNA reference
15:54built from various ancient hominins.
15:57The resulting mitochondrial DNA sequence
16:00closely resembled that of known Denisovans,
16:02supporting the idea that the Harbin individual
16:05belonged to or was closely related to
16:08this mysterious human group.
16:11Within the Denisovan group,
16:13Harbin's mitochondrial DNA is more similar to older Denisovans,
16:17Denisovans 2, 8, 19, 20, and 21,
16:20than to the two younger ones,
16:22Denisovans 3 and 4,
16:25suggesting an early divergence.
16:26Earlier studies based on the skull shape of Harbin
16:30had suggested it might belong to a new species
16:33or be closely related to Homo sapiens,
16:35but this new DNA study shows that Harbin clearly falls within the Denisovan genetic range.
16:42Since the Harbin skull is about 146,000 years old
16:46and shares similar DNA,
16:48this suggests Denisovans lived widely across Asia during the Middle Pleistocene.
16:53This discovery is important because it is the first time
16:56Denisovan DNA has been linked to physical features in a well-preserved fossil.
17:01It may help scientists identify other fossils,
17:04like those from Dali, Jinyushan, and Hualongdong,
17:08as Denisovan-related,
17:09even if DNA isn't available,
17:12by comparing bone structure.
17:14However, the conclusion is limited by the fact
17:16that only a small amount of mitochondrial DNA was recovered from Harbin
17:20and no nuclear DNA was found.
17:23The study of ancient DNA has revealed significant genetic differences
17:27between Denisovans and modern humans.
17:29Denisovan genomes differ from the standard human genome by 11.7%,
17:33while the difference between Neanderthals and modern humans is 12.2%.
17:38Denisovans and Neanderthals are closely related,
17:42but distinct from Homo sapiens.
17:44Denisovans show higher genetic diversity than Neanderthals,
17:48but lower diversity than modern humans,
17:50indicating a larger and more diverse population.
17:54Their geographic distribution ranged from North Asia to Southeast Asia.
17:59Denisovans carried genetic traits associated with dark skin,
18:03brown hair, and brown eyes,
18:04which are also present in modern humans.
18:07Denisovans likely played a role in adaptive introgression,
18:11where early Homo sapiens acquired genes from Denisovans
18:14that enhanced adaptation, disease resistance, and immune systems.
18:19The presence of human leukocyte antigens in modern humans,
18:23inherited from Denisovans, supports this hypothesis.
18:27For example, there is evidence that adaptation to high-altitude hypoxia
18:31among modern-day Tibetans is a result of introgression from Denisovans.
18:36There is an argument that interbreeding between humans and Denisovans
18:40occurred east of the Wallace's line,
18:42while another group argues that interbreeding occurred
18:46before humans crossed the Wallace's line.
18:48The distribution of Denisovan DNA in modern populations
19:07suggests significant interbreeding may have occurred
19:10after early humans crossed Wallace's line.
19:14Indigenous groups in New Guinea, Australia, and nearby islands
19:18exhibit the highest levels of Denisovan ancestry,
19:21reaching 3 to 4 percent.
19:24Interestingly, populations in mainland Asia,
19:27despite Denisovan's historical range,
19:30show lower levels of Denisovan DNA.
19:33This disparity indicates that Denisovan-modern human interactions
19:37were concentrated east of Wallace's line,
19:40likely shaped by migration and ecological boundaries.
19:43Mainland populations may have experienced a replacement effect,
19:48where later waves of East Asian populations diluted or replaced Denisovan DNA.
19:55Even in isolated groups like the Andaman islanders,
19:59who show no admixture with other populations,
20:02no Denisovan DNA has been found.
20:05Denisovans lived across both mainland and island Southeast Asia,
20:09thriving in diverse environments.
20:13During the Pleistocene, when sea levels dropped,
20:16vast savannah regions on the Sunda shelf, now submerged,
20:21likely served as migration routes and refuges for Denisovans during climate changes.
20:26This mobility may have allowed them to interact with modern humans in island Southeast Asia,
20:32resulting in genetic mixing.
20:35The only ancient human species known to have crossed Wallace's line before modern humans
20:40is Homo floresiensis.
20:43This species remains mysterious,
20:46as scientists are unsure of its exact evolutionary origins.
20:50Some studies suggest it evolved from an early ancestor of Homo erectus,
20:56or perhaps from an even older and more primitive human species.
21:00Evidence of stone tools on flores,
21:03dated to over one million years ago,
21:06indicates that these hominins arrived on the island very early.
21:10However, it's difficult to link Homo floresiensis to the Denisovans.
21:14The Denisovans had larger molars, teeth,
21:19which don't match the anatomy of Homo floresiensis.
21:22Moreover, genetic studies suggest that Denisovans and modern humans
21:27shared a common ancestor between 170,000 and one million years ago.
21:33This timeline makes it unlikely that Homo floresiensis,
21:37which had been isolated in the Wallacea region for so long,
21:41was directly related to the Denisovans.
21:43The Denisovans, on the other hand,
21:46likely arrived later, around 600,000 years ago,
21:50and spread across a wider area of Asia and Southeast Asia.
21:55Some Denisovan fossils may yet be undiscovered,
21:58but possible candidates could include the Homo luzonensis from Philippines
22:02or other mysterious human fossils found in places like
22:06Namada and Dali, Jinyushan, Maba, and Zhujiayao, China.
22:11These sites suggest that Denisovans, or other ancient human species,
22:17once had a much broader range than previously thought.
22:21Recently, evidence of human activity has been found in the Kashmir Valley,
22:25where around 300,000 to 400,000 years ago,
22:29humans relied on mammoth carcasses, which further supports this claim.
22:33The Denisovan genome reveals evidence of interbreeding with another ancient population.
22:40But the identity of this group remains a mystery.
22:44Scientists speculate that Denisovans might have mixed with older human species,
22:48like Homo erectus, Homo antecessor,
22:51or possibly a late-surviving Homo heidelbergensis in Asia.
22:55This raises intriguing questions about how many ancient human groups co-existed and interacted.
23:04The fossil evidence from East Asia is incomplete and scattered,
23:07but it hints at a rich diversity of hominin species.
23:12Discoveries like Homo floresiensis on Flores
23:15and the Homo luzonensis remains from Kalao Cave in the Luzon Island of Philippines
23:20suggest that multiple human groups once inhabited Wallasea.
23:25This raises the possibility that some early hominins
23:29might have even reached New Guinea and Australia.
23:32If true, it would mean ancient humans were far more adaptable
23:37and capable of long-distance migration than previously thought.
23:42Gene flow between Denisovans and modern humans
23:45occurred primarily east of Wallasea's line,
23:48likely because the circumstances of these encounters were unique.
23:53Crossing Wallasea's line required watercraft,
23:56which suggests that the first modern human groups reaching Wallasea
23:59were small and isolated.
24:02In such scenarios, interbreeding with the established Denisovan populations
24:06may have been more likely,
24:08as smaller populations often rely on intergroup mating
24:12to maintain genetic diversity.
24:14Additionally, genetic signals from these early interactions
24:18would be preserved more easily
24:20in the descendants of such small, founding populations.
24:24Interestingly, evidence suggests that this gene flow
24:27was predominantly male-mediated,
24:30meaning Denisovan males may have interbred with modern human females.
24:35This provides clues about the nature of these interactions,
24:39though much remains speculative.
24:41Rapid dispersal into the tropical regions of Wallasea
24:45likely exposed early modern humans to unfamiliar pathogens.
24:50Hybridization with Denisovans,
24:52who were already adapted to the local environment,
24:55may have provided disease-resistance genes
24:58that offered a survival advantage.
25:01This could have made interbreeding beneficial
25:03and increased the likelihood of these genetic traits
25:06being passed on and preserved.
25:08As genomic research progresses,
25:11it is expected to shed more light on these interactions,
25:15revealing how Neanderthal and Denisovan DNA
25:18contributed to the genetic makeup of modern humans
25:21and whether some of the exchanged DNA
25:23had functional significance,
25:26such as aiding in disease resistance
25:28or environmental adaptation.
25:30These discoveries are reshaping our understanding
25:35of human evolution in Asia,
25:38revealing it as a dynamic region
25:40where multiple human species likely interacted.
25:45The presence of Denisovans across such a wide geographic range,
25:49from Siberia to China to Southeast Asia,
25:53suggests they were a significant part of Asia's Pleistocene ecosystems.

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