Margaret Josephs reveals the medication she took to lose 22 pounds

  • last year
Margaret Josephs admits diet and exercise are not behind her slimmer physique.

The “Real Housewives of New Jersey” star revealed to People Tuesday that she’s lost 22 pounds by taking peptides and undergoing hormonal replacement therapy.

“It’s been life-changing,” Josephs told the magazine.

“And it’s not about being fat or skinny; it’s about every aspect of my wellness coming together.”

She added, “I wanted to feel healthy and get my body to a place where I’m supposed to be. I feel so lucky to have found something that’s really working for me.”

Josephs, 55, said she sought medical attention after she found it “very hard” to “maintain” her weight loss in recent years.

“I’d be working out, eating healthy, running around all the time and nothing — and everybody knows I don’t even drink alcohol, so that wasn’t it,” the fashion designer explained.

“I just wasn’t feeling my best self. I was feeling tired and sluggish. I struggled to find energy in the way I had in the past. I was dealing with some brain fog.”
Josephs’ physician assistant Jamie Gabel PA-C told People that he put the reality star on a wellness program that included hormone replacement, peptides to maintain her muscle mass and strengthen her joints, and a mixture of glucagon-like peptide-1 (GLP-1).

He said GLP-1 is utilized in the treatment of type 2 diabetes and obesity, and GLP-1 receptor Semaglutide is commonly sold under the names Wegovy, Rybelsus and Ozempic, the latter of which is known for being used as a “quick fix” weight-loss drug in Hollywood.

It is unclear whether Joseph’s cocktail contains Ozempic. However, the “RHONJ” star has been on her peptides since April 2022 and takes one daily, another shot five days a week and a third, once a week.
However, Gabel noted that his office does not use a “one-size fits all model” for all patients and also pointed out that the medications can cause “gastrointestinal-related” side effects such as nausea and constipation.

Josephs, for her part, is thrilled with her results and gushed to People, “I’m 126 pounds now, give or take a pound depending on the day, and I haven’t been that weight since I got married the first time in 1994.”

“It was the right cocktail for me,” she added. “My swelling has gone down in my arm. My skin’s gotten tighter. My bones stronger. I’m sleeping better, I have more energy.”

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