As of now we have tested and played Pokemon Scarlet and Violet on PC using the latest yuzu build for PC. As long as you have the latest firmware and keys you'll be able to boot up this game without any issues at all.
Official Site https://approms.com/pokesvryuzu
Tested with these PC Specs: CPU: Intel i7-8700 8th GEN Cpu GPU: Zotac RTX 2070 Super Twinfan RAM: 16GB DDR4 G.Skill Trident Z SSD: 1TB Samsung 970 EVO Plus HDD: 2x 3TB Seagate Barracuda CPU Cooler: ID Cooling Zoomflow 240XT PSU: Seasonic FOCUS Plus 850 Gold Case: NZXT H500